Abstract
Systemic Infection with Enteric Adenovirus in Immunocompetent Child with<i>Haemophilus influenzae</i>Disease
Highlights
Systematic 16S rRNA gene sequencing of atypical clinical isolates identified 27 new bacterial species associated with humans
Figure. 16S rDNA maximum-likelihood phylogenetic tree showing the relationships of a blood isolate with Atopobium species
GenBank accession numbers are indicated in brackets. 16S rDNA sequence of Actinomyces bovis was used as an outgroup
Summary
To the Editor: Recent articles have reported enteric human adenoviruses (HAdVs) types 40 and 41, previously thought to be restricted to the gastrointestinal tract (1), in multiple organ systems of a deceased immunodeficient child (2) and in respiratory specimens of children with acute respiratory illnesses (3). Detection of virus in the acute-phase serum specimen confirms systemic infection and demonstrates that HAdV-40 DNA found in CSF did not arise from contamination of the CSF at the time of collection. The patient had been receiving antimicrobial drug therapy for several days, his CSF was negative for 16S bacterial RNA by PCR and culture-negative for H. influenzae, and the CSF pleocytosis had decreased substantially These circumstances make it less likely that these signs were associated with the underlying H. influenzae disease and raise the possibility that superimposed HAdV-40 infection played a role.
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