Abstract
Since its initial description (1–3), popliteal lymph node assay (PLN assay) in rats has long been considered to be a “loco-regional” form of graft-versus-host reaction (GVHR). Recently Grebe and Streilein have demonstrated the existence of a systemic component expressed mainly by splenomegaly and distant lympha-denopathy (4). If the assay has a widely disseminated expression, it should be possible to detect an immunomodulation identical to the regulatory mechanisms arising during a classic systemic GVH (GVH disease, GVHD), such as the survival and recovery of the host, and the refractoriness to a new specific or nonspecific challenge (5–7) (GVHR resistance). In this report, the possible systemic GVHR resistance induced by a PLN assay has been tested in two models of GVHR: GVHD, and PLN assay. In this latter model the first GVHR was induced on one hind footpad whereas the challenge inoculum was performed on the controlateral footpad.
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