Systemic Immune-Inflammation Index Predicts the Clinical Outcome in Patients with mCRPC Treated with Abiraterone.

Cristian Lolli,Ugo De Giorgi,Francesca Maines,Vincenza Conteduca,Antonello Veccia,Michele Aieta,Emanuela Bianchi,Vincenzo E Chiuri,Francesco Massari,Orazio Caffo,Gaetano Facchini,Emanuela Scarpi

doi:10.3389/fphar.2016.00376

Abstract

Background: A systemic immune-inflammation index (SII) based on neutrophil (N), lymphocyte (L), and platelet (P) counts has shown a prognostic impact in several solid tumors. The aim of this study is to evaluate the prognostic role of SII in metastatic castration-resistant prostate cancer (mCRPC) patients treated with abiraterone post docetaxel.Patients and Methods: We retrospectively reviewed consecutive mCRPC patients treated with abiraterone after docetaxel in our Institutions. X-tile 3.6.1 software, cut-off values of SII, neutrophil-to-lymphocyte ratio (NLR) defined as N/L and platelets-to-lymphocyte ratio (PLR) as P/L. Overall survival (OS) and their 95% Confidence Intervals (95% CI) was estimated by the Kaplan-Meier method and compared with the log-rank test. The impact of SII, PLR, and NLR on overall survival (OS) was evaluated by Cox regression analyses and on prostate-specific antigen (PSA) response rates were evaluated by binary logistic regression.Results: A total of 230 mCRPC patients treated abiraterone were included. SII ≥ 535, NLR ≥ 3 and PLR ≥ 210 were considered as elevated levels (high risk groups. The median OS was 17.3 months, 21.8 months in SII < 535 group and 14.7 months in SII ≥ 535 (p < 0.0001). At univariate analysis Eastern Cooperative Oncology Group (ECOG) performance status, previous enzalutamide, visceral metastases, SII, NLR, and PLR predicted OS. In multivariate analysis, ECOG performance status, previous enzalutamide, visceral metastases, SII, and NLR remained significant predictors of OS [hazard ratio (HR) = 5.08, p < 0.0001; HR = 2.12, p = 0.009, HR = 1.77, 95% p = 0.012; HR = 1.80, p = 0.002; and HR = 1.90, p = 0.001, respectively], whereas, PLR showed a borderline ability only (HR = 1.41, p = 0.068).Conclusion: SII and NLR might represent an early and easy prognostic marker in mCRPC patients treated with abiraterone. Further studies are needed to better define their impact and role in these patients.

Highlights

Prostate cancer is the most common cancer and the second cause of death for cancer in men (Siegel et al, 2016)
The effect of inflammation in prognosis and progression has been shown in patients with metastatic castration-resistant prostate cancer (mCRPC), and peripheral blood circulating cells included in inflammation indices have been associated with prognosis in these patients (De Marzo et al, 2007; Brennen et al, 2013; Leibowitz-Amit et al, 2014; Lorente et al, 2015; Conteduca et al, 2016)
Neutrophil-to-lymphocyte ratio (NLR) has shown a prognostic role in patients with mCRPC when treated with abiraterone, enzalutamide, docetaxel, or cabazitaxel (Leibowitz-Amit et al, 2014; Nuhn et al, 2014; Lorente et al, 2015; Conteduca et al, 2016)

Summary

Introduction

Prostate cancer is the most common cancer and the second cause of death for cancer in men (Siegel et al, 2016). The effect of inflammation in prognosis and progression has been shown in patients with mCRPC, and peripheral blood circulating cells (neutrophils, lymphocytes and platelets) included in inflammation indices have been associated with prognosis in these patients (De Marzo et al, 2007; Brennen et al, 2013; Leibowitz-Amit et al, 2014; Lorente et al, 2015; Conteduca et al, 2016). NLR has shown a prognostic role in patients with mCRPC when treated with abiraterone, enzalutamide, docetaxel, or cabazitaxel (Leibowitz-Amit et al, 2014; Nuhn et al, 2014; Lorente et al, 2015; Conteduca et al, 2016). The aim of this study is to evaluate the prognostic role of SII in metastatic castration-resistant prostate cancer (mCRPC) patients treated with abiraterone post docetaxel

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