Abstract
The principal aim of this work was to analyze the host systemic immune response to an oral infection of A. viscosus T14V. Previous work bad established a Balb/c mouse model for A. viscosus T14V oral infection. Animals were infected and the splenocyte response to A. viscosus T14V antigens, LPS, and Con A were assessed in the lymphoblast assay. Splenocytes from mice infected with A. viscosus T14V exhibited an altered response pattern to the antigens and mitogens. The responses were enhanced or suppressed when compared to the uninfected control splenocyte response. The effluent celis from a nylon wool column were unresponsive to A. viscosus antigens but LPS did respond to Con A. This response pattern was true for splenocytes from infected and uninfected animals.These results suggest that A. viscosus T14V is a potent immunomodulater when analyzed within the Balb/c mouse model system.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
