Abstract
Systemic Effects of Radiotherapy in Ductal Carcinoma In Situ
Highlights
The methods used in this epidemiologic database analysis were rigorous
It is of interest that estrogen receptor– positive status was more common in patients treated by lumpectomy with radiotherapy than in the groups treated with lumpectomy alone or mastectomy, potentially resulting in a higher use of endocrine therapy in the former group compared with the latter two
How do the results of this observational study compare with those from prospective controlled studies? Previous randomized trials have demonstrated that whole-breast irradiation following lumpectomy for ductal carcinoma in situ (DCIS) substantially reduces local invasive and noninvasive recurrences but have been unable to demonstrate an effect on breast cancer mortality.[2,3]
Summary
The methods used in this epidemiologic database analysis were rigorous. Investigators were careful to match for year and age at diagnosis, tumor grade, estrogen receptor status, and propensity score, taking into account ethnicity, household income, tumor size, and progesterone receptor status.
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