Abstract

Ordinarily allergic eczematous contact dermatitis is produced by external exposure of the skin to an allergen. Occasionally, however, in sensitized individuals a systemically administered allergen may reach the skin via the circulatory system and produce a hematogenous contact-type dermatitis. Although the eczematous condition is produced by systemic administration, the first sensitizing exposure to the allergen may have been by topical application. In such instances, an eczematous contact-type of eruption may be produced not only by the sensitizing allergen, but also by the allergens that are immunochemically related. 1 Previous ingestion of an allergen can also have an influence on later contact sensitization in man. Ingestion of an allergen by a person previously sensitized by contact may result in a variety of reactions. Most frequent reactions are focal flares at sites of previous dermatitis. Occasionally, dyshidrotic eruptions can occur as well as generalized eruptions. Sometimes, such flares may even occur from inhalation of the allergen.

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