Abstract
Objectives: Increased expression of interferon-beta (IFN-β) was shown in patients with insufficient coronary collateralization. Furthermore, mice treated with IFN-β demonstrate inhibition of collateral artery growth, known as arteriogenesis. IFN-β is also involved in atherosclerosis and in atherosclerotic mouse models, IFN-β treatment accelerated lesion formation whereas in mice lacking myeloid interferon-α/β receptor subunit 1 (IFNAR1) atherosclerosis was decreased, with less accumulation of macrophages and reduced plaque cell death.
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