Abstract
Antibodies to four Bordetella pertussis antigens (filamentous haemagglutinin (FHA), lymphocytosis-promoting factor (LPF), lipopolysaccharide (LPS) and a 69-kilo-dalton protein (69-KD)) were measured by enzyme-linked immunosorbent assay (ELISA) in serum and saliva specimens of 29 children with typical whooping cough, of whom 11 were culture positive. Twelve (41%) had IgM antibody detectable in the acute serum. All 13 (100%) on whom paired sera were obtained showed a rise in antibody levels. Eleven of 19 (58%) had IgA antibody detectable on the acute saliva specimen, and antibody was more likely to be present in children with a longer history. Antibodies to LPF were most prevalent in serum, but those to FHA and 69-KD were most prevalent in saliva. Serum Bordetella pertussis antibody measurement by ELISA appears useful in confirming the diagnosis but paired samples are needed for full sensitivity; secretory IgA antibody assay using saliva may be a promising new approach.
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