Abstract
Vaccination is considered crucial for the eradication of the coronavirus disease (COVID-19). In our medical center in Korea, most health care workers (HCWs) were vaccinated with the ChAdOx1 COVID-19 vaccine. After vaccination, many HCWs complained of adverse events (AEs). However, it remains unclear whether the production of neutralizing antibodies (NAb) was affected. Therefore, here, we aimed to evaluate AEs and early NAb production in relatively healthy Asians who received the ChAdOx1 vaccine and determine the effect of AEs and antipyretics on early NAb production against COVID-19. Of the 182 Korean HCWs who received the first dose of ChAdOx1 vaccine, 172 (94.5%) experienced ≥1 adverse events and 148 (81.3%) tested positive for NAb 33–40 days after the vaccination. NAb-positive vaccine recipients reported systemic AEs and consumed acetaminophen more frequently than NAb-negative recipients. We identified an association between antibody response and COVID-19 vaccine-related AEs. In conclusion, most ChAdOx1 vaccine recipients reported AEs in our medical center.
Highlights
The coronavirus disease (COVID-19) is an ongoing global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Many health care workers (HCWs) complained of adverse events (AEs) with varying characteristics and severity [1,2,3]
Between 4 March 2021 and 10 March 2021, 1356 HCWs were vaccinated with the first dose of ChAdOx1 vaccine at our hospital
Summary
The coronavirus disease (COVID-19) is an ongoing global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Countries worldwide have emphasized the need for social distancing, wearing a facemask, and proper personal hygiene to prevent the spread of SARS-CoV-2 in the community. While the role of non-pharmaceutical interventions in preventing disease transmission has limitations, vaccination is crucial for the eradication of COVID-19. In Korea, vaccination began on 26 February 2021, starting with health care workers (HCWs) and patients in nursing hospitals. Most HCWs were vaccinated with the ChAdOx1 COVID-19 vaccine. Many HCWs complained of adverse events (AEs) with varying characteristics and severity [1,2,3]. There was little reference data on the AEs because Asians were only
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
