Abstract
Wollastonite (CaSiO3; CSi) ceramic is a promising bioactive material for bone defect repair due to slightly fast degradation of its porous constructs in vivo. In our previous strategy some key features of CSi ceramic have been significantly improved by dilute magnesium doping for regulating mechanical properties and biodegradation. Here we demonstrate that 6 ~ 14% of Ca substituted by Mg in CSi (CSi-Mgx, x = 6, 10, 14) can enhance the mechanical strength (>40 MPa) but not compromise biological performances of the 3D printed porous scaffolds with open porosity of 60‒63%. The in vitro cell culture tests in vitro indicated that the dilute Mg doping into CSi was beneficial for ALP activity and high expression of osteogenic marker genes of MC3T3-E1 cells in the scaffolds. A good bone tissue regeneration response and elastoplastic response in mechanical strength in vivo were determined after implantation in rabbit calvarial defects for 6‒12 weeks. Particularly, the CSi-Mg10 and CSi-Mg14 scaffolds could enhance new bone regeneration with a significant increase of newly formed bone tissue (18 ~ 22%) compared to the pure CSi (~14%) at 12 weeks post-implantation. It is reasonable to consider that, therefore, such CSi-Mgx scaffolds possessing excellent strength and reasonable degradability are promising for bone reconstruction in thin-wall bone defects.
Highlights
Wollastonite (CaSiO3; CSi) ceramic is a promising bioactive material for bone defect repair due to slightly fast degradation of its porous constructs in vivo
In our previous strategy some key features of CSi ceramic have been significantly improved by dilute magnesium doping for regulating mechanical properties and biodegradation
We found that the mechanical properties of CSi ceramic could be significantly enhanced by being doped with limited amount of Mg (Mg substituting Ca by 0–17 mol%: CSi-Mgx, x = 0–17)
Summary
Wollastonite (CaSiO3; CSi) ceramic is a promising bioactive material for bone defect repair due to slightly fast degradation of its porous constructs in vivo. Wollastonite (CaSiO3; CSi), which exhibited faster degradation rate and higher osteogenesis, has received a great deal of attention This ceramics is superior to traditional calcium phosphates in cell attachment, proliferation and differentiation[18]. We found that the mechanical properties of CSi ceramic could be significantly enhanced by being doped with limited amount of Mg (Mg substituting Ca by 0–17 mol%: CSi-Mgx, x = 0–17) Such CSi-Mgx ceramic exhibited significantly improved densification, excellent fracture toughness (>3.2 MPa m1/2), and good bioactivity in SBF (simulated body fluid) in vitro[24]. It is reasonable to hypothesize that this expected improvement in physicochemical and mechanical properties could qualify 3D porous CSi-Mgx bioceramics to reconstruct certain challengeable thin-wall bone defects
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
