Systematic Understanding of the Mechanism of Salvianolic Acid A via Computational Target Fishing.

Shao-Jun Chen,Ming-Chao Cui

doi:10.3390/molecules22040644

Shao-Jun Chen, Ming-Chao Cui

Open Access

https://doi.org/10.3390/molecules22040644

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Journal: Molecules (Basel, Switzerland)	Publication Date: Apr 17, 2017
Citations: 30	License type: CC BY 4.0

Affiliation: Zhejiang Pharmaceutical College

Abstract

Salvianolic acid A (SAA) is one of the most abundant water-soluble and potent anti-oxidative compounds isolated from Danshen, a traditional Chinese medicine. A systematic overview of its mechanism of action is yet to be performed. In the present study, the druggability of SAA was measured using the TCMSP server, and potential targets of SAA were identified by PharmMapper and DRAR-CPI. Intersecting targets were then assessed by GeneMANIA and GO pathway analysis, and drug-target-pathway networks were constructed to give a visual view. The results showed that SAA has good druggability, and 13 putative protein targets were identified. Network analysis showed that these targets were associated with cancer, metabolism and other physiological processes. In summary, SAA is predicted to target multiple proteins and pathways to form a network that exerts systematic pharmacological effects.

Highlights

Traditional Chinese medicine (TCM) and natural products in general are the best source of active compounds for drug discovery [1,2]
Salvianolic acid A (SAA; Figure 1a) is one such example, and is one of the most abundant water-soluble components extracted from Danshen, a TCM that has been widely used to treat cardiovascular diseases for hundreds of years [3,4]
The DL of SAA was calculated to be of ASS were investigated in depth by TCMSP (Table 1)

Summary

Introduction

Traditional Chinese medicine (TCM) and natural products in general are the best source of active compounds for drug discovery [1,2]. Salvianolic acid A (SAA; Figure 1a) is one such example, and is one of the most abundant water-soluble components extracted from Danshen (red sage, or Radix Salvia miltiorrhiza), a TCM that has been widely used to treat cardiovascular diseases for hundreds of years [3,4]. Anti-inflammation and antioxidant, myocardial ischemic protection, antithrombotic, neuroprotection and anti-fibrosis activities have been reported, and it can prevent diabetes and associated complications [4,6]. For such naturally occurring compounds, knowledge of the toxic or medicinal properties often long predates precise knowledge of targets or mechanisms [1], and there remains much to learn about SAA

Methods

Results

Discussion

Conclusion