Systematic review of sarcomas radiomics studies: Bridging the gap between concepts and clinical applications?

Abstract

ObjectivesSarcomas are a model for intra- and inter-tumoral heterogeneities making them particularly suitable for radiomics analyses. Our purposes were to review the aims, methods and results of radiomics studies involving sarcomas MethodsPubmed and Web of Sciences databases were searched for radiomics or textural studies involving bone, soft-tissues and visceral sarcomas until June 2020. Two radiologists evaluated their objectives, results and quality of their methods, imaging pre-processing and machine-learning workflow helped by the items of the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2), Image Biomarker Standardization Initiative (IBSI) and ‘Radiomics Quality Score’ (RQS).Statistical analyses included inter-reader agreements, correlations between methodological assessments, scientometrics indices, and their changes over years, and between RQS, number of patients and models performance. ResultsFifty-two studies were included involving: soft-tissue sarcomas (29/52, 55.8 %), bone sarcomas (15/52, 28.8 %), gynecological sarcomas (6/52, 11.5 %) and mixed sarcomas (2/52, 3.8 %), mostly imaged with MRI (36/52, 69.2 %), for a total of distinct patients. Median RQS was 4.5 (28.4 % of the maximum, range: -7 – 17). Performances of predictive models and number of patients negatively correlated (p = 0.027). None of the studies detailed all the items from the IBSI guidelines. There was a significant increase in studies’ impact factors since the establishing of the RQS in 2017 (p = 0.038). ConclusionAlthough showing promising results, further efforts are needed to make sarcoma radiomics studies reproducible with an acceptable level of evidence. A better knowledge of the RQS and IBSI reporting guidelines could improve the quality of sarcoma radiomics studies and accelerate clinical applications.