Systematic Review of microRNAs in the SARS-CoV-2 Infection: Are microRNAs Potential Therapy for COVID-19?

Sevgin Omer,Sevgin Kubra

doi:10.23937/2378-3648/1410053

Abstract

COVID-19 is a highly infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Although the exact diagnosis, clinical and treatment features for SARS-CoV-2 infection have not been determined yet, the accumulation of knowledge is increasing day by day. However, there is still insufficient information about the cellular and molecular regulation of SARS-CoV-2. The development of miRNA targeting anti-viral therapies in the literature has attracted great interest and have been considered as promising biomarker(s) and novel target(s) for therapeutic approaches.

Highlights

Coronaviruses are a group of single stranded RNA viruses with viral spike proteins on their surface [1]
This review summarizes potential mRNA-inhibiting RNAs (miRNAs) that can be targeted for the further therapies of SARS-CoV-2 infections
A general review of current studies concerning the function of miRNAs in SARS-CoV-2 infection, and available therapeutic prospects to mitigate the burden of viral infections were presented

Summary

Introduction

Coronaviruses are a group of single stranded RNA viruses (ssRNA) with viral spike proteins on their surface [1]. The E protein is Citation: SEVGIN O, SEVGIN K (2021) Systematic Review of microRNAs in the SARS-CoV-2 Infection: Are microRNAs Potential Therapy for COVID-19?. Most of the SARS-CoV-2 and miRNA related studies have been made in silico analysis, there are some studies that present potential miRNA gene regulations experimentally.

Results

Conclusion