Systematic Review of Literature Documenting the Link between BMI, Sperm Parameters, and Leptin

Abstract

Background: Leptin administration to rats causes adverse effects on sperm that resemble those reported in obese males. The purpose of this review is, therefore, to examine whether human and animal studies have taken this information on board and have attempted to link the poor sperm quality in obese or overweight individuals to leptin in their methodology, data analysis, and discussion. The review also documents the link between low sperm quality in the obese and leptin. Method: A search was made for articles reporting body mass index (BMI), sperm parameters, and leptin, published until September 2020 in PubMed, Science Direct, Google Scholar, and Springer Link using a number of search terms. Results: Forty-four of the 53 human and animal studies on BMI and sperm parameters reported abnormal sperm parameters in the obese but only 9 of those had measured serum leptin. None, however, attempted to link sperm abnormalities to leptin. Nine animal studies report of adverse effects of leptin on sperm in normal weight rats that were found to be similar to those reported in obese males. Conclusion: Although none of the human studies had actually linked the raised leptin to sperm abnormalities in the obese, there is nevertheless, convincing evidence linking leptin to obesity-related poor sperm quality and male infertility. There is a need, therefore, to include measures that will help reduce the impact of raised leptin levels on male reproductive function, particularly, in obese infertile or subfertile males.