Abstract
Introduction: Diabetes mellitus is a complex metabolic clinical condition. It induces some irreversible pathological changes in the body, which rise to multiple complications. Moreover, the side effects of the established anti-hyperglycemic agents in contemporary science on their long-term use make it more worst. Considering the higher incidence rate of Diabetes mellitus due to faulty lifestyle, it is essential to think over various safe but effective measures in alternative science. i.e., Ayurveda. In Ayurveda, diabetes mellitus can be correlated with Prameha or Madhumeha due to similarity in signs & clinical features.
 Aim & Objective: The prime aim of this study is to study the efficacy and safety of different Shodhana & Shamana Chikitsa in Ayurveda for glucose control & improvement in clinical features during the management of Diabetes Mellitus Type II(Prameha W.S.R).
 Materials & Methods: This is a meta-analysis of Ayurvedic interventions in Shodhana, or Shamana Chikitsa used to manage Prameha (Diabetes mellitus type II). On extensive Review of the literature, 42 clinical studies (R.C.T. & N.R.C.T.) fulfilling inclusion criteria & conducted with 1743 participants at different places were critically analyzed. Adequate details of the individual studies were tabulated and discussed.
 Observations & Results: It is reflected that the combinations of both these interventions are more effective than only Shaman Chikitsa in the management of Diabetes mellitus.
 Conclusion: All of these interventions in Ayurveda reviewed through this study are appeared to be generally safe and effective, having a prime or adjuvant role. However, Ayurvedic physicians should prescribe them based on their clinical judgment, patient’s references, type of pathology, chronicity of the disease & strength of the patient.
Highlights
Diabetes mellitus is a complex metabolic clinical condition
After Sansarjana Karma, the patient was assessed for clinical features of Prameha, which showed significant results, which concluded that Rookshana Poorvaka Virechana Karma is highly beneficial in the management of Sthula Madhumeha [7]
Diabetes mellitus is a clinical condition that is strongly characterized by elevated blood sugar levels due to primary or secondary deficiency of insulin
Summary
Diabetes mellitus is a complex metabolic clinical condition. It induces some irreversible pathological changes in the body, which rise to multiple complications. Aim & Objective: The prime aim of this study is to study the efficacy and safety of different Shodhana & Shamana Chikitsa in Ayurveda for glucose control & improvement in clinical features during the management of Diabetes Mellitus Type II(Prameha W.S.R). The prevalence of Diabetes has been rising more rapidly in low and middle-income countries than in high-income countries [1,2,3,4]. It is the leading cause of 2.6% of global blindness & kidney failure [4]. Adults with Diabetes have a two- to three-fold increased risk of heart attacks and strokes
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