Abstract
Understanding the assembly mechanisms of RNA viruses is key to controlling these agents' replication. This process, however, involves a complex interplay between capsid proteins and the genome in contraposition to dsDNA viruses, where the capsid formation precedes the incorporation of the genetic material. Mean-field theoretical approaches have stressed the relevance of electrostatics, persistence length, and secondary structure. In addition, other methodologies have pointed to the importance of sequence-specific sites in the capsid proteins, which guide the folding process. In the present contribution, we attempt to complement these efforts by reconstructing the entire 3D structure of a virus by building an optimal RNA model, including the information of the sequence, secondary structure, and some structural fragments determined experimentally.
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