Abstract
Aging of the skin due to exposure of UV rays is referred as photoaging. Photoaging causes dry skin, wrinkles, darker skin pigmentation, and reduced skin firmness. The effect of photoaging can be treated by compounds that have antioxidant activity. Coffee contains polyphenols (caffeic acid and chlorogenic acid) which can inhibit the formation of ROS free radicals. This makes coffee an antioxidant potential in photoaging treatment. This study aims to determine the effectiveness of coffee extract as an antioxidant in photoaging treatment. The method used in this study is Systematic Literature Review. A comprehensive literature search was conducted using the Harzing's Publish or Perish application on several databases, such as Google Scholar, PubMed, Scopus, and Crossref using the keywords "coffee AND antioxidant AND ultraviolet AND photoaging". The article selection flow used the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) protocol. The total search results were 1202 articles, and there were 6 research articles that matched the inclusion and exclusion criteria that had been set. The results of this study concluded that coffee extract can be used as an antioxidant in photoaging treatment. The effectiveness of coffee extract as an antioxidant in photoaging treatment was demonstrated by reducing the expression of MMPs, increasing the expression of type 1 procollage, reducing the area of wrinkles, and reducing TEWL. Coffee leaf extract decreased the expression of MMPs (MMP-1 ¯ 50%, MMP-3 ¯ 10% to 60%, MMP-9 ¯ 30% to 50%) and increased type 1 procollagen 60%. Coffee bean extract decreased the expression of MMPs (MMP-1 ¯ 5% to 60%, MMP-2 ¯ 20% to 60%, MMP-3 ¯ 30%, MMP-9 ¯ 20% to 70%, MMP-13 ¯ 30% to 45%), increased type 1 procollagen 10% to 60%, reduced wrinkle area 20% to 88%, and decreased TEWL 10% to 20%.
Highlights
Aging of the skin due to exposure of UV rays is referred as photoaging
This study aims to determine the effectiveness of coffee extract as an antioxidant in photoaging treatment
Evaluation of Antibiotics Use in Post-Surgical Acute Appendicitis Patients at ThePasuruan Regency General Hospital in 2018 (The Study Was Conducted atInpatient Installation of Pasuruan Regency General Hospital)
Summary
Kulit merupakan bagian terluar dari tubuh yang berfungsi melindungi dari berbagai macam gangguan dan rangsangan dari luar. Penuaan kulit dapat disebabkan dari faktor intrinsik dan ekstrinsik. Sedangkan penuaan kulit ekstrinsik disebabkan oleh faktor yang berasal dari luar seperti ekspresi wajah berulang, polusi serta paparan sinar matahari terutama sinar ultraviolet (UV) (2). Penuaan kulit ekstrinsik yang dipengaruhi oleh sinar ultraviolet (UV) disebut juga sebagai photoaging. Tanaman kopi dapat digunakan sebagai antioksidan karena memiliki kandungan polifenol dalam biji kopi sebesar [37-55] mg GAE/g dan daun kopi sebesar [12-77] mg GAE/g(5). Peneliti ingin melakukan penelitian lebih lanjut menggunakan systematic literature review untuk mengetahui efektivitas aktivitas antioksidan yang ditimbulkan oleh kopi dalam mengatasi photoaging dengan melihat parameter MMPs (Matrix Metalloproteinase), prokolagen tipe 1, area kerutan, dan TEWL (Transepidermal Water Loss). Setiap pertanyaan dengan jawaban “yes” akan mendapatkan poin +1 dan jawaban “no”, “unclear”, serta “not applicable” mendapatkan poin 0
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