Abstract
Primary immune thrombocytopenia (ITP) is an autoimmune disease. However, the molecular mechanisms underlying ITP remained to be further investigated. In the present study, we analyzed a series of public datasets (including GSE43177 and GSE43178) and identified 468 upregulated mRNAs, 272 downregulated mRNAs, 134 upregulated lncRNAs, 23 downregulated lncRNAs, 29 upregulated miRNAs, and 39 downregulated miRNAs in ITP patients. Then, we constructed protein-protein interaction networks, miRNA-mRNA and lncRNA coexpression networks in ITP. Bioinformatics analysis showed these genes regulated multiple biological processes in ITP, such as mRNA nonsense-mediated decay, translation, cell-cell adhesion, proteasome-mediated ubiquitin, and mRNA splicing. We thought the present study could broaden our insights into the mechanism underlying the progression of ITP and provide a potential biomarker for the prognosis of ITP.
Highlights
Primary immune thrombocytopenia (ITP) is an autoimmune disease characterized by a decrease in platelets due to platelet destruction and insufficient platelet production [1, 2]
Previous studies had showed the increasing antiplatelet antibodies produced by B cells, and the aberrant functions of T lymphocytes were involved in regulating the progression of ITP [3]
Liu et al identified a total of 1177 and 632 Long noncoding RNAs (lncRNAs) were significantly upregulated or downregulated in ITP patients compared to normal samples [9]
Summary
Primary immune thrombocytopenia (ITP) is an autoimmune disease characterized by a decrease in platelets due to platelet destruction and insufficient platelet production [1, 2]. Previous studies had showed the increasing antiplatelet antibodies produced by B cells, and the aberrant functions of T lymphocytes were involved in regulating the progression of ITP [3]. Noncoding RNAs, such as miRNAs and lncRNAs, played important roles in the progression of human diseases [4]. MiRNAs were a type of ncRNAs with 19-25 bps in length and regulated gene expression and protein translation by targeting 3-UTR of mRNAs. Previous studies showed miRNAs were dysregulated and associated with the regulation of ITP. Liu et al identified a total of 1177 and 632 lncRNAs were significantly upregulated or downregulated in ITP patients compared to normal samples [9]. We screened differently expressed mRNAs, miRNAs, and lncRNAs in ITP compared to normal samples using two public datasets, GSE43177 and GSE43178.
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