Systematic evaluation and meta analysis of children bronchial pneumonia treated with tanreqing injection

Abstract

Objective To evaluate the effectiveness and safety of tanreqing injection to children bronchial pneumonia. Methods PubMed, Ovid, CNKI, and data retrieval system of all places were searched to identify relevant studies from 2003 to November of 2014. The final documents were examined with inclusive and exclusive criteria. Results were pooled with meta-analysis on RevMan software to assess the efficacy of tanreqing injection to children bronchial pneumonia. Results The database was derived from 13 qualified studies that included a total of 1479 patients. Meta analysis showed that, compared to the control group, tanreqing injection treatment group resulted in higher effective rate [OR=2.96, 95% CI(2.22, 3.96), P<0.01], shorter time of recovering the normal temperature [MD=-0.53, 95% CI(-0.77, -0.29), P<0.01], shorter time of disappearance of cough [MD=-1.25, 95% CI(-2.14, -0.37), P<0.01], shorter time of lung rale [MD=-1.00, 95% CI(-1.4, -0.6), P<0.01], and shorter time of hospitalization time [MD=-1.35, 95% CI(-1.83, -0.86), P<0.01]. Significant difference was observed between control and treatment groups. Conclusions This study showed that tanreqing injection appeared to be more effective for children bronchial pneumonia. However, methodology showed low quality. The efficacy needs high-quality clinical trials to verify. Key words: Bronchopneumonia/ZD; ANTIPYRETIC-DETOXICATE AGENTS/TU; INJECTIO; Meta-analysis