Abstract
AbstactBackgroundEpilepsy, one of the most common neurological disorders, affects over 70 million people worldwide. Rhynchophylline displays a wide variety of pharmacologic actives. However, the pharmacologic effects of rhynchophylline and its mechanisms against epilepsy have not been systematically elucidated.MethodsThe oral bioavailability and druglikeness of rhynchophylline were evaluated using the Traditional Chinese Medicine Systems Pharmacology Database. Rhynchophylline target genes to treat epilepsy were identified using PharmMapper, SwissTargetPrediction and DrugBank databases integration. Protein-protein interaction analysis was carried out by utilizing the GeneMANIA database. WebGestalt was employed to perform Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses. The drug-disease-target-Gene Ontology-pathway network was constructed using Cytoscape.ResultsThe oral bioavailability and druglikeness of rhynchophylline were calculated to be 41.82% and 0.57, respectively. A total of 20 rhynchophylline target genes related to epilepsy were chosen. Among the 20 genes and their interacting genes, 54.00% shared protein domains and 16.61% displayed co-expression characteristics. Gene ontology, Kyoto Encyclopedia of Genes and Genomes and network analyses illustrate that these targets were significantly enriched in regulation of sensory perception, morphine addiction, neuroactive ligand-receptor interaction and other pathways or biological processes.ConclusionIn short, rhynchophylline targets multiple genes or proteins, biological processes and pathways. It shapes a multiple-layer network that exerts systematic pharmacologic activities on epilepsy.
Highlights
IntroductionOne of the most common neurological disorders, affects over 70 million people worldwide
Epilepsy, one of the most common neurological disorders, affects over 70 million people worldwide
A total of 20 rhynchophylline target genes related to epilepsy were chosen
Summary
One of the most common neurological disorders, affects over 70 million people worldwide. Epilepsy is a chronic nervous system disorder that exhibits abnormal brain activities, periods of unusual behavior or seizures, and sensations [1]. It affects over 70 million people of all ages worldwide. Uncaria rhynchophylla (U. rhynchophylla), for example, is a vital TCM that has been widely utilized in many Asian countries for centuries [3]. It is known as Gou Teng in China, and found throughout Southern of China, including regions such as, Guangxi, Sicuan, Yunnan, and Fujian [4]. U. rhynchophylla belongs to the Rubiaceae family [4] and exerts a wide variety of pharmacologic activities, like anti-inflammatory effects and neurotransmitter regulation [3]
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