Systematic characterization of non-coding RNAs in triple-negative breast cancer.

Jie Mei,Leiyu Hao,Yan Liu,Huiyu Wang,Yichao Zhu,Chaoying Liu,Rui Xu

doi:10.1111/cpr.12801

Abstract

Triple‐negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer with negativity for oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor (HER2). Non‐coding RNAs (ncRNAs) make up most of the transcriptome and are widely present in eukaryotic cells. In recent years, emerging evidence suggests that ncRNAs, mainly microRNAs (miRNAs), long ncRNAs (lncRNAs) and circular RNAs (circRNAs), play prominent roles in the tumorigenesis and development of TNBC, but the functions of most ncRNAs have not been fully described. In this review, we systematically elucidate the general characteristics and biogenesis of miRNAs, lncRNAs and circRNAs, discuss the emerging functions of these ncRNAs in TNBC and present future perspectives in clinical practice.

Highlights

In the past few decades, the morbidity of human breast cancer has increased continuously and has led to a great threat to women's lives
According to the statistics gathered by the American Cancer Society, there will be more than 271 000 new cases of breast cancer and approximately 42 260 deaths in 2019.1 Being a heterogeneous disease, breast cancer can be classified into several main subclasses based on the expression status of oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor (HER2) and antigen ki-67 (Ki-67).[2]
Triple-negative breast cancer (TNBC) is the most aggressive subtype, which is characterized by negativity for ER, PR and HER2

Summary

Introduction

In the past few decades, the morbidity of human breast cancer has increased continuously and has led to a great threat to women's lives. The expression of lncRNA PNUTS was elevated and associated with levels of ZEB mRNAs. PNUTS served as a competitive sponge for miR-205 during epithelial-mesenchymal transition.[86] Besides, PDCD4-AS1 regulated breast cancer progression through stabilizing PDCD4 RNA by forming RNA duplex and controlling the interaction between PDCD4 RNA and RNA decay-promoting factors such as HuR.[87] the role of lncRNAs in regulating mRNA stability has been rarely observed, it is a novel mechanism that lncRNA-related biological process needs to be further explored in the future.

Results

Conclusion