Systematic approach to the assessment of suicidal behavior (618.22)

Abstract

The research and modern literature data suggest the organizational structure of behavioral suicidal act. The impact of stress factors in the external and internal environment causes a negative psycho‐emotional reaction.The severity of this reaction will depend largely on the state of stress‐limiting systems. In turn, psycho‐emotional response will depend on a number of related factors: genetic, previously carried diseases, disorders, psycho‐social environment; disorders of neuro‐vegetative regulation peculiarities and mental reactions, hormonal status (cortisol, prolactin, thyroid hormones and bioactive connections, etc.), availability of previous alcoholism or drug addiction; metabolic features of the body and brain, in particular, the level of cholesterol in the blood, disorders of the immune system, etc. An important element in the formation of functional and pathological disorders of the central nervous system is a hormonal link. Our data indicate that more than 58% of suicide population (girls) holds inconsistency adaptive and compensatory mechanisms, expressed in varying degrees. Girls with more severe rehabilitation period, but with a stable hyperprolactinemia have significant increase in cortisol levels (2.22 times) is accompanied by a relatively less pronounced increase in prolactin levels (1.8 times), resulting in a low rate of BPD/K. This may indicate that persistent hyperprolactinemia against kortizolemia can be one of the factors that shape disrupting the mechanism of adaptation, in particular the failure of its stress‐limiting link. Conditions of formation of suicidal activity have been originated from these factors. At their worst combination is a qualitatively new emotional state with an orientation to suicide. Study of the functional constituents of the system and the determination of their role in the system will effectively act on these components and prevent suicide attempts.