Abstract
In this study, the purification of an extract from Artemisia annua L. using chromatographic methods is studied. In a first step, a screening of different phases and solvents using thin-layer chromatography (TLC) was performed. Then, a laboratory-scale high performance liquid chromatography (HPLC) method was developed and transferred to a pilot scale. A reproducibility study based on 120 injections was carried out. The batch process that was developed and the results from a designed continuous simulated moving bed (SMB) chromatography were compared based on characteristic process numbers and economy.
Highlights
The demand for naturally derived pharmaceuticals continues to grow [1,2]
Previous studies have shown that the substance could be extracted by solid–liquid extraction (SLE) using percolation or pressurized hot water extraction (PHWE) [3]
The purification is performed by liquid–liquid extraction (LLE) chromatography and a final crystallization [3,4,5,6,7,8,9,10,11,12]
Summary
The demand for naturally derived pharmaceuticals continues to grow [1,2]. Pharmaceuticals, in contrast to food supplements and natural plant protection agents from plant extracts, must be purified.One example is the anti-malaria agent artemisinin, which is extracted from Artemisia annua L. The demand for naturally derived pharmaceuticals continues to grow [1,2]. Pharmaceuticals, in contrast to food supplements and natural plant protection agents from plant extracts, must be purified. One example is the anti-malaria agent artemisinin, which is extracted from Artemisia annua L. This agent is administered as a pure substance. The plant extract must be purified to pharmaceutical grade. The purification is performed by liquid–liquid extraction (LLE) (see Part II) chromatography and a final crystallization (see Part IV) [3,4,5,6,7,8,9,10,11,12]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
