System Organization of Clinical Symptoms and EEG-Characteristics of Patients with Depressive Disorders in Harmonic Sound Therapy

Elena Grigorieva

doi:10.11648/j.cnn.20180203.11

Abstract

The work is devoted to the search for the systemic organization of clinical symptoms and EEG characteristics of patients with recurrent depressive disorders. It determines the effect of harmonic sound in accordance with the extremes of the maximum and/or minimum EEG spectrum on clinical and EEG characteristics of patients, loosening of stable pathological relationships in order to reduce or eliminate depression. The study involved 58 patients. 35 of them were diagnosed with prolonged and chronic depressive disorder, which to no avail was treated with various antidepressants of the group of SSRIs in combination with benzodiazepines or small doses of atypical (olanzapine, sulpiride) or classical (chlorprotixen, sonapax) antipsychotics. At the time of sound therapy, the drugs were not canceled. 22 patients had repeated depressive episode in the past (two to four weeks ago), untreated. The search for the systemic organization of clinical symptoms and EEG characteristics was carried out using analytical mathematics. In this section factor analysis with factor rotation were used. The positive outcome of the sessions of sound exposure, as well as the reaction to the sound of the last session (no drowsiness or vigor, there is a weakening or elimination of depression), and the number of sessions depended on the removal of the most stable combinations of symptoms (according to the HAM- D scale). They reflected the reciprocity of their own symptoms of depression and anxiety in both groups of patients and made a "hard link" of the system. Other combinations of symptoms-flexible links of the system-are less stable. Acting on them in a stable pathological condition (depression) are less radical. Harmonic sound effects cause a significant restructuring of the background EEG observed at the time of exposure and after it in both groups of patients. The features of EEG in patients in complete or incomplete remission, as well as in the absence of the effect of treatment. Neurophysiological "hard link" of the system organization of EEG characteristics could not be identified. An attempt to explain the results is made. Perhaps the "hard link" of the system organization of EEG characteristics is at a different energy level or requires a different mathematical approach.

Highlights

Depressive disorder is a multiple factor process
Each patient, depending on the duration and quality of the therapeutic effect, underwent from 3 to 15 sessions of sound exposure followed by filling in the HAM-D scale as a rule, repeated sessions were the day after the return of depression
Factor Analysis in the Group of Patients Treated with Psychopharmacological Drugs Along with Harmonic Sound

Summary

Introduction

Depressive disorder is a multiple factor process. Understanding of its complexity, variability, ambiguity of prognosis, criteria, and approaches to therapy is increasing. Bioelectric brain activity is a multiple factor process. It is characterized by great complexity, variability and nonspecifity. EEG (16 channels according to the international standard), EEG at the time and after sound exposure were recorded in all patients. On their basis the "Brainlog" program carried out a spectral analysis of the EEG, in which there were the extremes of maximum (exceeding the amplitude of the neighboring frequenciesharmonics) and extreme minimum (equal to the amplitude of the neighboring frequencies-harmonics). The harmonic sound was individual, had its range of sound effects according to the extremes with a 2n factor. Each patient, depending on the duration and quality of the therapeutic effect, underwent from 3 to 15 sessions of sound exposure followed by filling in the HAM-D scale as a rule, repeated sessions were the day after the return of depression

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Discussion

Conclusion