Abstract
Objective To evaluate the association of vaginal dysbiosis and infertility. Methods Cohort studies, case-control studies and cross-sectional studies were searched in electronic databases, including MEDLINE, EMBASE and SinoMed (from inception to October 2017); in addition, the reference lists of included studies and similar reviews were handsearched. These studies investigating the correlation between vaginal dysbiosis and infertility were included. The Meta-Analysis was performed by RevMan 5.3 software. Results 1 724 records were retrieved by the search; from those, 9 cross-sectional studies were included, comprising 3 367 participants (1 702 in infertility group and 1 665 in control group). The likelihood of vaginal dysbiosis in infertility group is higher than that of control group[OR=3.15, 95% CI (1.57, 6.32), P=0.001]. Conclusions The available evidence suggests that vaginal dysbiosis was associated with the incidence of infertility. However, further case-control studies or cohort studies are required to confirm or refute these findings.(Chin J Lab Med, 2018, 41: 281-286) Key words: Infertility, female; Vagina; Microbiota; Dysbiosis; Meta-analysis
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