Abstract
In tetrahydrofuran, the condensation of aldehydes and ketones with different salts of α-bromo acids yields, after hydrolysis, the corresponding β-hydroxy acids. This reaction can be brought about in a single stage, according to the Reformatsky traditional method, or else in two stages: preliminary preparation of the organozinc, then condensation with carbonyl compounds. This method, applied to α-ethylenic aldehydes and ketones, leads to 1,2-addition products. Different parameters of the reactions are studied. Some new β-hydroxy acids are described. The stereochemistry of the reactions between organozinc of α-bromobutyric acid and benzaldehyde or acetophenone are little influenced by the nature of solvent.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
