Synthetic versatility: the C-P bond odyssey.

Abstract

C-P bond formation reactions have garnered significant attention due to the widespread presence of organophosphorus compounds in pharmaceuticals, phosphine-containing ligands, pesticides, and materials science. Consequently, various efficient methodologies have been established in recent decades for constructing C-P bonds. This review article traces the historical evolution of C-P bond research and explores the prospects of C-P bond formation. It contrasts biotechnological approaches with chemical synthesis, emphasizing the critical importance of precision and innovation in developing novel C-P structures. A forward-looking perspective is provided on the role of computational tools and machine learning in optimizing C-P bond synthesis and discovering new compounds. The article explores prospective avenues for reactions that form C-P bonds and advocates for enhanced interdisciplinary collaboration to propel scientific and technological advancements.