Synthetic Study on Human C-Peptide and its Related Peptides

Abstract

Syntheses of eighteen peptides related to human C-peptide and the connecting peptide are described. The syntheses were performed exclusively by the azide fragment condensation method. The immunochemical results justified the utilization of these peptides for development of human C-peptide radioimmunoassay system. The synthetic peptide fragments may be extremely important substrates for assessment of specificity of human C-peptide antisera and thus usefulness of the antisera in practical measurement of blood levels of human C-peptide immunoreactivity.