Abstract
A new synthetic pathway to lythraceae alkaloid lasubine II has been developed. In this approach, we designed a sequential cyclization pathway for the formation of quinolizidine ring. For the preparation of the requisite precursor, a known chiral β-amino ester has been used as a starting intermediate. Upon deprotection of Cbz group on nitrogen, endo-type Michael addition and the following S N2 reaction were assumed to proceed to provide (−)-2- epi lasubine II.
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