Abstract
A tandem 5-exo-trig-vinyl-3-exo-radical cyclization-rearrangement reaction and its allylic radical version was developed (8 & 15 to 9 & 16 respectively) for the synthesis of DEF ring system of the nor-tritepene Pfaffic acid 1.
Highlights
Nishimoto et al isolated[2] Pfaffic acid, 1 a novel hexacyclic nortriterpenoid from the Brazilian plant Pfaffia paniculata kuntze along with its glycoside derivatives called Pfaffosides
In vitro studies demonstrated that pfaffic acid and pfaffosides show high inhibitory effects towards various types of cancer cells such as melanoma B-16, hela S-3 and lewis lung carcinogen cells even at very low concentrations.[3]
Pfaffic acid with its unique structure, having the presence of ten asymmetric centers, coupled with its promising anti-tumor activities prompted us to initiate a program towards its total synthesis
Summary
Nishimoto et al isolated[2] Pfaffic acid, 1 a novel hexacyclic nortriterpenoid from the Brazilian plant Pfaffia paniculata kuntze along with its glycoside derivatives called Pfaffosides.
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