Abstract

The key transformation for the total synthesis of the lindenane sesquiterpenoid dimers is the intermolecular Diels–Alder reaction between two lindenane-type monomers. Herein we report our efforts made on examination of the biogenetic hypothesis and the inverse-electron-demand Diels–Alder (IEDDA) reaction. The combination of Tf2NH/AlMe3 was developed to catalyze the model IEDDA reaction.

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