Abstract
The synthesis of indolo[2,3- a]quinolizidin-2-one 15 is reported through the potassium tert-butoxide cyclization of N-hydroxyethyl-2-[1-(phenylsulfonyl)-3-indolyl]-4-piperidone ethylene acetal ( 5) into 3-spiroindolenine intermediate 6. Anhydrous acid treatment of 6 leads to the rearranged 2,3-indole substituted compound 14. The reactivity of intermediate 6 will be further applied to construct ring C of Strychnos and Aspidosperma framework.
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