Abstract
Synthetic process towards the bottom half portion of C 20 oxygenated series of bryostatins is described. The stereogenic center at C 20 position was constructed through a hydroxyl group-directed epoxidation by using mCPBA. It was found that silver (I) salt is an effective and mild reagent for regioselective ring cleavage of α-bromoepoxides into the corresponding α-hydroxyketones via oxonium ion intermediates.
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