Synthetic studies on 3-arylquinazolin-4-ones: intramolecular nucleophilic aromatic substitution reaction of 2-carboxamido-3-arylquinazolin-4-ones and its application to the synthesis of secondary aryl amines

Abstract

The general synthesis and a novel intramolecular nucleophilic aromatic substitution (S NAr) reaction of 2-carboxamido-3-arylquinazolin-4-ones, a potentially useful scaffold in the field of medicinal chemistry, are described. The synthetic utility of the S NAr reaction as a tool for the synthesis of secondary aryl amines, including diaryl amines, is also demonstrated.