Abstract
The synthesis of a new asymmetric ligand (E)-4-bromo-2-(((2-((5-bromo-2-hydroxybenzyl)(methyl)amino)ethyl)imino)methyl)phenol, which was conceived to model the asymmetry in the active site of peroxidase/catalase mimics, is reported. The new synthetic route involves seven steps: 1) obtention of phthalimido-acetal; 2) Acetal deprotection; 3) Synthesis of the salicylamine; 4) Obtention of the benzoxacine; 5) Reduction of the benzoxacine with NaBH3CN; 6) Reduction with hydrazine to form salycilamine; 7) Synthesis of the final ligand by condensation of salicylamine with salycilaldehyde. All organic products were characterised by microanalysis and 1H NMR, IR and mass spectroscopies.
Highlights
The synthesis of the new asymmetric ligand (E)-4-bromo-2-(((2-((5-bromo-2hydroxybenzyl)(methyl)amino)ethyl)imino)methyl)phenol, which was conceived to model the asymmetry in the active site of peroxidase/catalase mimics, is reported
All organic products were characterised by microanalysis, 1H NMR, IR and mass spectroscopies
Br δ(‐H)(7) δ(Harom)(2),(8) δ(‐CH2‐)(6) δ (‐CH2‐)(3) δ (‐CH2‐)(5) δ(‐CH3)(4)
Summary
Synthetic route to novel asymmetric tetradentate ligands containing both amino and imino groups González-Noya,2 Rosa Pedrido,2 Laura Rodríguez,1 Marcelino Maneiro1,*
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
