Synthetic Retinoid Kills Drug‐Resistant Cancer Stem Cells via Inducing RARγ‐Translocation‐Mediated Tension Reduction and Chromatin Decondensation (Adv. Sci. 31/2022)

Abstract

Mechanism of Synthetic Retinoid Kills Cancer-Stem-Cell-Like Cells In article number 2203173, Xing Cao, Ning Wang, Junwei Chen, and co-workers reveal the mechanism of synthetic retinoid WYC-209 overcomes the limitation of conventional anticancer drugs by inducing tension-abrogation mediated chromatin decondensation and DNA damage to kill cancer-stem-cell-like cell tumor repopulating cells. This finding provides a new perspective strategy of lowering cell tension and decondensing chromatin to enhance efficacy of anti-cancer drugs to abrogate metastasis of cancer stem cell like cells.