Abstract
AbstractSince the mid-1980s, the family of high molecular weight glycoproteins known as mucins have evoked considerable interest among those in the field of cancer research. Mucins, which are constituents of mucus, have a lubricating and protective function in normal epithelial tissue (1). However, expression of mucin by the cancer cell is often highly disorganized and upregulated, sometimes to the extent that mucin can be detected in the circulation of the cancer patient. These changes in expression of mucin observed in neoplasia have led to the exploitation of some members of the mucin family as circulating tumor markers (2,3) or targets for diagnostic imaging (4–6) and therapy of cancer. KeywordsHigh Molecular Weight GlycoproteinFmoc DeprotectionConjugation BufferDispense Amino AcidSodium Dihydrogen OrthophosphateThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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