Abstract
Six new synthetic routes to 2,2-dimethyl-6-oxo-1-cyclohexaneacetic acid (1) from readily available starting materials have been evaluated. The most efficient method (yield 35%) involves alkylation of Hagemann's ester with ethyl bromoacetate followed by hydrolysis of the resultant ethyl 3-(ethoxycarbonyl)-2-methyl-6-oxo-1-cyclohexeneacetate to unsaturated keto acid 2-methyl-6-oxo-1-cyclohexeneacetic acid (19) and then treatment of 19 with Me2CuLi. A method from mesityl oxide is longer and slightly less efficient (30%). These two methods are suitable for a large-scale preparation of 1.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
