Abstract
通过点击化学(Click chemistry)与原子转移自由基聚合(ATRP)一锅法合成AB型嵌段聚合物聚乙二醇嵌段聚甲基丙烯酸羟乙酯(PEG-b-PHEMA),之后对所得聚合物进行组氨酸(His)修饰得到p H敏感型聚合物PEG-b-PHEMA(His),运用核磁共振(1H NMR)及凝胶渗透色谱(GPC)表征了该嵌段聚合物及组氨酸修饰后的产物的结构和分子量分布(Mn=8.2×103~13.0×103 g/mol,PDI=1.27~1.51),说明聚合物被成功地合成且具有较小的多分散系数.之后对嵌段聚合物PEG-b-PHEMA(His)进行了动态光散射(DLS)、透射电镜(TEM)和临界胶束浓度(CMC)的测试,结果表明,聚合物胶束呈球形且粒径分布均匀,并且粒径随组氨酸接枝率增大而减小.最后我们做不同接枝比的PEG-b-PHEMA(His)的酸碱滴定曲线,结果表明,组氨酸的接入使聚合物具备明显的p H响应能力,进一步的释药试验也证明了这一结果.
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