Synthetic nanosrystalline calcium phosphate materials for facing defects of bone and insuffication of muscular tissue and their synthesis

Abstract

An assessment was made of the possibility of using nanocrystalline materials of calcium phosphate composition to fill defects in bone tissues and as inorganic fillers of composite materials to fill the lack of muscle tissue. Optimum compositions and firing temperatures of synthetic nanocrystalline materials have been determined which have a controlled rate of bioresorption, increased resistance to dissolution by body fluids, and also with controlled pathways for the withdrawal of metabolites. It is established that bioceramics can be obtained at a temperature of 1100 - 1200 ° C of a mixture of nanocrystalline powders of previously synthesized components: Са3(PO4)2 , Са10(PO4)6(OH), Са10(PO4)6F2, Mg(С17H35COO)2. A positive effect of the Mg(С17H35COO)2 impurity on low-temperature activation of the synthesis of nanocrystalline structures. Specific features of the process of bioresorption of the developed calcium phosphate materials have been established. Changes in the surface of samples after in vivo tests by electron microscopy were studied. The dynamics of the content of metabolites of synthesized materials and microelements in organs and tissues in vivo is established. An increase in the calcium content in the kidneys and liver of experimental animals was detected. This indicates the ways of withdrawal of bioresorbtion products. It is determined that synthesized materials are promising for tissue engineering. Due to their chemical composition and biological properties, they can be used to fill defects in bone tissues and as inorganic fillers of fillers to compensate for the lack of muscle tissue. The introduction of the developed technology will help solve the problem of providing modern materials with restorative surgery. At the same time, this will improve the quality of life of a large number of people with pathological or age-related loss of muscle tissue or skeletal tissue