Synthetic Modifications of Lead Compounds as Antitrypanosomal Drugs

Abstract

first_page settings Order Article Reprints Font Type: Arial Georgia Verdana Font Size: Aa Aa Aa Line Spacing:    Column Width:    Background: Open AccessAbstract Synthetic Modifications of Lead Compounds as Antitrypanosomal Drugs by H. Cerecetto 1, R. Di Maio 1, G. Seoane 1, A. Denicola 2, G. Peluffo 3 and C. Quijano 3 1 Cátedra de Química Orgánica, Facultad de Química, Universidad de la República. General Flores 2124, Montevideo, Uruguay 2 Departamento de Fisicoquímica Biológica, Facultad de Ciencias, Universidad de la República. General Flores 2124, Montevideo, Uruguay 3 Departamento de Bioquímica, Facultad de Medicina, Universidad de la República. General Flores 2124, Montevideo, Uruguay Molecules 2000, 5(3), 497-498; https://doi.org/10.3390/50300497 Published: 22 March 2000 Download Download PDF Download PDF with Cover Download XML Download Epub Versions Notes Abstract: Following our work in the synthesis of compounds with antichagasic activity, we describe new potential products in which the same “leader” compound was modulated. IntroductionWe have previously reported the synthesis and biological activity against Trypanosoma cruzi epimastigote forms in vitro and in vivo, of a series of semicarbazone derivatives of 5-nitrofurfural (“leader” compounds) [1,2]. ExperimentalThe synthesis of the new compounds is shown in the following scheme: This compounds (I-IX), treated with Lawesson’ reagent, produced the thiocarbonyl compounds. Results and DiscussionThe new compounds were identified by 1H-NMR, 13C-NMR, IR, MS and were tested in vitro against epimastigote forms of Trypanosoma cruzi. Acknowledgements The authors thank PEDECIBA Química and RELAQ (Red Latinoamericana de Ciencia Química).References and NotesCerecetto, H.; Di Maio, R.; Ibarruri, G.; Seoane, G.; Denicola, A.; Peluffo, G.; Quijano, C.; Paulino, M. Synthesis and anty-trypanosomal activity of novel 5-Nitro-2-furaldehyde and 5-Nitrotiophene-2-carboxaldehyde semicarbazones derivatives. Il farmaco 1998, 53, 89–94. [Google Scholar] [CrossRef] Cerecetto, H.; Di Maio, R.; González, M.; Risso, M.; Sagrera, G.; Seoane, G.; Denicola, A.; Peluffo, G.; Quijano, C.; Basombrío, M.A.; Stoppani, A.O.M.; Paulino, M.; Olea-Azar, C. Synthesis and anty-trypanosomal evaluation of E-isomers of 5-nitro-2-furaldehyde and 5-Nitrotiophene-2-carboxaldehyde semicarbazones. Eur. J. Med. Chem. (in press). Share and Cite MDPI and ACS Style Cerecetto, H.; Di Maio, R.; Seoane, G.; Denicola, A.; Peluffo, G.; Quijano, C. Synthetic Modifications of Lead Compounds as Antitrypanosomal Drugs. Molecules 2000, 5, 497-498. https://doi.org/10.3390/50300497 AMA Style Cerecetto H, Di Maio R, Seoane G, Denicola A, Peluffo G, Quijano C. Synthetic Modifications of Lead Compounds as Antitrypanosomal Drugs. Molecules. 2000; 5(3):497-498. https://doi.org/10.3390/50300497 Chicago/Turabian Style Cerecetto, H., R. Di Maio, G. Seoane, A. Denicola, G. Peluffo, and C. Quijano. 2000. "Synthetic Modifications of Lead Compounds as Antitrypanosomal Drugs" Molecules 5, no. 3: 497-498. https://doi.org/10.3390/50300497 Find Other Styles Article Metrics No No Article Access Statistics For more information on the journal statistics, click here. Multiple requests from the same IP address are counted as one view.