Synthetic Methods for Diarylamines and Triarylamines

Abstract

Molecules that contain secondary amines and tertiary amines play important roles in many different areas of chemistry, for example in biologically important natural products and pharmaceuticals; also, they have lots of applications in materials research. Different routes have been reported for the selective synthesis of secondary amines and tertiary amines, including the Ullmann reaction and Buchwald–Hartwig amination. These methods suffer from several drawbacks including a lack of tolerance towards functional groups and harsh reaction conditions. For these reasons, the development of a convenient and efficient method for the synthesis of secondary amine and tertiary amine derivatives takes on a significant meaning. This book, and especially this chapter, aims to provide a concise overview of methods found in both basic and applied chemical research. In this chapter, a brief history of secondary and tertiary amine synthesis is presented, followed by recent improvements and extensions of the methodology.