Abstract
Background While late gadolinium enhanced (LGE) MRI is the gold standard for detection of focal myocardial scarring [1], it is less effective than cardiac T1 mapping (ECV) for detection of diffuse fibrosis. LGE, in principle, can be synthesized from cardiac T1 maps. We sought to derive synthetic LGE images from saturation-recovery based cardiac T1 maps for simultaneous assessment of focal and diffuse cardiac fibrosis.
Highlights
While late gadolinium enhanced (LGE) MRI is the gold standard for detection of focal myocardial scarring [1], it is less effective than cardiac T1 mapping (ECV) for detection of diffuse fibrosis
We imaged 6 mongrel dogs with lesions created by RF ablation on a 3T MRI system (Verio, Siemens), using arrhythmia-insensitive-rapid (AIR) cardiac T1 mapping [2] and standard LGE MRI during equilibrium of Gd-BOPTA, in order to compare standard and synthetic LGE images acquired at identical concentration of Gd-BOPTA
We propose a new approach to simultaneously assess focal and diffuse cardiac fibrosis using cardiac T1 mapping, with no need for separate acquisition of standard LGE images
Summary
While late gadolinium enhanced (LGE) MRI is the gold standard for detection of focal myocardial scarring [1], it is less effective than cardiac T1 mapping (ECV) for detection of diffuse fibrosis. LGE, in principle, can be synthesized from cardiac T1 maps. We sought to derive synthetic LGE images from saturation-recovery based cardiac T1 maps for simultaneous assessment of focal and diffuse cardiac fibrosis
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