Abstract
Several new series of very potent, selective inhibitors of human neutrophil elastase (HNE), an enzyme implicated as a pathogenic agent in pulmonary emphysema, have recently been reported. Diane Amy Trainor discusses the preliminary pharmacological evaluation of several of these new compounds in animal models of lung injury, which indicates that they have the necessary profile to properly evaluate the protease-anti-protease hypothesis of emphysema in the clinic.
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