Synthetic Genomics and Synthetic Biology Applications Between Hopes and Concerns

Daniel Frank,Reinhard Heil,Christopher Coenen,Harald Konig

doi:10.2174/1389202911314010003

Abstract

New organisms and biological systems designed to satisfy human needs are among the aims of synthetic genomics and synthetic biology. Synthetic biology seeks to model and construct biological components, functions and organisms that do not exist in nature or to redesign existing biological systems to perform new functions. Synthetic genomics, on the other hand, encompasses technologies for the generation of chemically-synthesized whole genomes or larger parts of genomes, allowing to simultaneously engineer a myriad of changes to the genetic material of organisms. Engineering complex functions or new organisms in synthetic biology are thus progressively becoming dependent on and converging with synthetic genomics. While applications from both areas have been predicted to offer great benefits by making possible new drugs, renewable chemicals or clean energy, they have also given rise to concerns about new safety, environmental and socio-economic risks – stirring an increasingly polarizing debate. Here we intend to provide an overview on recent progress in biomedical and biotechnological applications of synthetic genomics and synthetic biology as well as on arguments and evidence related to their possible benefits, risks and governance implications.

Highlights

Giving an unequivocal definition of synthetic biology is challenging, even to the various actors in the field ([1,2,3] and references therein)
New organisms and biological systems designed to satisfy human needs are among the aims of synthetic genomics and synthetic biology
We intend to provide an overview on recent progress in biomedical and biotechnological applications of synthetic genomics and synthetic biology as well as on arguments and evidence related to their possible benefits, risks and governance implications

Summary

Introduction

Giving an unequivocal definition of synthetic biology is challenging, even to the various actors in the field ([1,2,3] and references therein). Complex gene circuits have been generated, such as those used to detect multiple changes in cancer cells [13], or computer-modeled, sophisticated non-natural metabolic pathways to produce chemicals and fuels have been constructed [14, 15].

Results

Conclusion