Abstract
Manipulating DNA transcription using synthetic DNA binder has always been one of the ideal strategies for biological regulation and disease therapy, in the premise of considerable efficacy. Although it has been studied for decades, synthetic DNA binder is gradually less popular for researchers from the aspects of structural study, wide biological exploration and clinical application. The partial reasons arise from less sequence selectivity and difficulty to install advanced working moiety on the scaffold of synthetic DNA binder. In order to closely study its structural domain and potential optimization approaches, here I discuss the architecture engineering of DNA binding system and how to construct advanced DNA binding assembly based on the well-studied DNA binding system Pyrrole–imidazole polyamides (PIPs). The recent progress on structural assembly and biological application are extensively introduced.
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