Abstract
New and useful asymmetric reactions have been developed based on the concept of "Synthetic Control". The concept of "Synthetic Control" is characterized by the utilization of common metal chelates for inter-or intramolecular interactions leading to highly stereospecific or entropically advantageous reactions. A variety of optically active compounds are obtained in much higher enantiomeric purities, compared with conventional methods, by utilizing chiral heterocyclic compounds such as chiral pyrrolidine or oxazepine derivatives, which have strong interactions with organometallic compounds to form tight complexes as intermediates. Similarly, asymmetric intramolecular Diels-Alder reactions are realized by the utilization of effective intramolecular metal chelation. Various natural products are successfully synthesized by the application of these reactions.
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