Abstract
This study deals with synthesis of methyl cinnamate, butyl cinnamate, and p-methoxy methyl cinnamate and testing of their in vitro antimicrobial activity. Antimicrobial activity was examined towards 29 microorganisms using microdilution method. It is shown that antimicrobial activity of methyl cinnamate and p-methoxy methyl cinnamate was better than that of butyl cinnamate. Sarcina lutea, Bacillus subtilis ATCC 6633, B. subtilis and B. subtilis IP 5832 (probiotic) were the most sensitive bacteria. It is established that p-methoxy methyl cinnamate can be a new, potential anti-Staphylococcus aureus agent with minimum inhibitory concentration of 62.5 ?g/ml. Methyl cinnamate and p-methoxy methyl cinnamate inhibited the growth of Aspergillus restrictus, A. flavus and A. fumigatus in the concentration range from 62.5 ?g/ml to 250 ?g/ml.
Highlights
This study deals with synthesis of methyl cinnamate, butyl cinnamate, and p-methoxy methyl cinnamate and testing of their in vitro antimicrobial activity
The results of in vitro testing of antibacterial and antifungal activities of cinnamates in relation to 29 species of microorganisms are shown in Tables 1 and 2
minimum inhibitory concentration (MIC) values were in range from 15.6 to >1000 μg/ml while minimum microbicidal concentration (MMC) values were from 31.25 to >1000 μg/ml
Summary
This study deals with synthesis of methyl cinnamate, butyl cinnamate, and p-methoxy methyl cinnamate and testing of their in vitro antimicrobial activity. It is shown that antimicrobial activity of methyl cinnamate and p-methoxy methyl cinnamate was better than that of butyl cinnamate. Cinnamates can be found in nature as secondary metabolites widely distributed in the plant kingdom They are synthesized by plants and, represent components of essential oils. Due to the characteristic flavour and fragrance, as well as high boiling point and stability, synthetic methyl, ethyl- and butyl cinnamate are widely used in food industry, especially for beverages and baked goods. The cinnamic acid derivatives showed different biological activities like antioxidant, antidiabetic, heaptoprotective, anti-inflammatory, cytotoxic, etc. There is limited information about antimicrobial activity of cinnamates as synthesized compounds, the aims of this work were to synthesize and to estimate the antimicrobial effects of methyl cinnamate, butyl cinnamate, and p-methoxy methyl cinnamate on broad panel of bacteria and fungi
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