Synthetic biology-based interactive biohybrid materials

Abstract

Event Abstract Back to Event Synthetic biology-based interactive biohybrid materials Wilfried Weber1* 1 University of Freiburg, Centre for Biological Signalling Studies BIOSS, Germany Synthetic Biology aims at the design and implementation of biological systems with desired properties using a modular approach based on well-characterized biological building blocks. Key building blocks are regulatory elements that can be used to externally control the functionality of a biological system in space and time. Recent work has shown that such control elements can be transferred from synthetic biology to material sciences for the synthesis of stimuli-sensing biohybrid materials the properties of which can be tuned by small molecules in vitro and in mouse models for drug delivery and tissue engineering applications. For applications in drug delivery we demonstrate the synthesis of a humanized pharmacologically controlled biohybrid hydrogel that can be used to release drugs such as vaccines in response to an external stimulus. We demonstrate the functionality of this depot in mice by designing a single-injection formulation of an anti-papillomavirus vaccine. For applications in tissue engineering we describe the synthesis of biohybrid materials that respond to physical or pharmacological stimuli by changing their mechanical and biological properties. We demonstrate the suitability of these materials to dynamically expose (stem) cells to desired cues for controlling cell signaling and migration. Keywords: Drug delivery, stimuli-response, Environmental response, biofunctional molecule Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: New Frontier Oral Topic: Environmentally sensitive biomaterials Citation: Weber W (2016). Synthetic biology-based interactive biohybrid materials. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.01269 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Mar 2016; Published Online: 30 Mar 2016. * Correspondence: Dr. Wilfried Weber, University of Freiburg, Centre for Biological Signalling Studies BIOSS, Freiburg, Germany, Email1 Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Wilfried Weber Google Wilfried Weber Google Scholar Wilfried Weber PubMed Wilfried Weber Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.