Abstract
Monocyclic β-lactams with appropriate amide-activating substituents possess antibacterial activity which rivals that of the traditional bicyclic penicillins and cephalosporins. The pharmaceutical potential of this discovery has spawned a high level of interest in the synthesis of these compounds. This review focusses on recent advances in the chemistry of the monocyclic β-lactams with particular attention to methods for the synthesis of enantiomerically pure azetidinones via the use of chiral starting materials or asymmetric induction. The literature from 1983 through early 1989 is discussed.
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